Status:
COMPLETED
A Study to Assess Regional Cerebral Blood Flow as an Alzheimer's Disease Biomarker Compared to Positron Emission Tomography in Patients With Mild-to-Moderate Alzheimer's Disease and Cognitively Normal Elderly Subjects (Study MK-0000-068)(COMPLETED)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
55+ years
Phase:
PHASE1
Brief Summary
The aim of the study is to determine if regional cerebral blood flow, measured by dynamic arterial spin labeling (dASL), can be a biomarker for stage of Alzheimer's disease. The study is designed to b...
Eligibility Criteria
Inclusion
- The prospective participant must meet, at least, all of the criteria below (among others determined by the study staff) to be eligible for study participation.
- The participant:
- Has mild-to-moderate Alzheimer's Disease (AD), OR is considered cognitively normal;
- Has been on stable doses of any regularly used medications for 4 weeks prior to study start;
- Must have been on a stable dose for 12 weeks prior to study start, of any medications taken for AD.
Exclusion
- If the prospective participant meets any of the criteria below (among others determined by the study staff) they will NOT be eligible for study participation.
- The participant:
- Is living in a nursing home or skilled nursing facility;
- Has severe AD;
- Cannot undergo MRI;
- Cannot undergo PET scans;
- Has a history of neurological or neurodegenerative disorders, other than AD within 2 years prior to study start;
- Has taken Tacrine or anti-parkinsonian medications within 3 months of study start;
- Has taken corticosteroids, blood thinners, narcotic analgesics, benzodiazepines, or certain antihistamines within 1 month of study start;
- Initiates, discontinues, or changes the dose of any AD treatment during the study.
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00757939
Start Date
September 1 2008
End Date
October 1 2010
Last Update
August 11 2015
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