Status:
COMPLETED
Using Rheological Methods to Characterize Cystic Fibrosis (CF) Sputum and the Effects of Mucoactive Agents
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
Genentech, Inc.
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
18-65 years
Brief Summary
The purpose of this study is to characterize the rheological properties of cystic fibrosis (CF) and healthy sputum and to examine the effects of mucoactive agents on the rheology of CF and healthy spu...
Detailed Description
There are two major mechanisms for mucus clearance in the airway, both of which are dependent upon optimal mucus viscosity and elasticity. These mechanisms are severely impaired in cystic fibrosis. Th...
Eligibility Criteria
Inclusion
- Healthy control subjects:
- Age 18-65
- No history of lung disease or cardiac disease
- Cystic fibrosis subjects:
- Age 18-65
- Diagnosis of CF - sweat chloride values \> 60 mM on pilocarpine iontophoresis sweat tests and/or 2 allelic CF-producing mutations by genetic analysis
Exclusion
- Use of recreational drugs within 1 year prior to enrollment
- Use of tobacco within 1 year prior to enrollment, or \> 10 pack-year tobacco history
- Upper respiratory tract infection in the 4 weeks prior to enrollment in the study
- Current use of antihistamines to treat allergies
Key Trial Info
Start Date :
October 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT00758771
Start Date
October 1 2007
End Date
December 1 2012
Last Update
March 5 2014
Active Locations (1)
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1
UCSF Airway Clinical Research Center
San Francisco, California, United States, 94143-0130