Status:
COMPLETED
Vitamin E and Infection in the Elderly
Lead Sponsor:
Tufts University
Conditions:
Respiratory Infection
Elderly
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
Aging is associated with a variety of changes in the immune system. These changes result in a less effective immune response, which places the elderly at a greater risk for infection and disease. Resp...
Eligibility Criteria
Inclusion
- aged 65 years or older;
- life expectancy greater than 6 months;
- no anticipated discharge within 3 months;
- not room-bound for the past 3 months;
- absence of active neoplastic disease;
- no tube feeding, no kidney dialysis;
- no intravenous or urethral catheters for the last 30 days;
- no tracheostomy or chronic ventilator;
- antibiotic-free for more than 2 weeks;
- no long-term steroid treatment greater than 10 mg/d, no use of immunosuppressive drugs, or greater than the recommended daily allowance (RDA) level of supplements of vitamins E, C, or B6, selenium, zinc, beta-carotene, or fish oil;
- body mass index of at least 18;
- serum albumin at least 3.0 g/dL; able to swallow pills;
- willing to receive influenza vaccine;
- willing to provide informed consent (for patients with dementia, family members provided informed consent)
Exclusion
Key Trial Info
Start Date :
May 1 1997
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00758914
Start Date
May 1 1997
Last Update
September 25 2008
Active Locations (1)
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1
Tufts University
Boston, Massachusetts, United States, 02111