Status:
COMPLETED
Safety and Efficacy Study of A Novel Ointment to Treat Plaque Type Psoriasis
Lead Sponsor:
Pfizer
Conditions:
Psoriasis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of the study is to determine the safety and efficacy of AN2728 Ointment, 5%, compared to Ointment Vehicle in the treatment of plaque type psoriasis.
Detailed Description
This is a multi-center, randomized, double-blind bilateral design. Patients will apply the test articles, AN2728 Ointment, 5%, and Ointment Vehicle twice daily. The assigned study medication will be a...
Eligibility Criteria
Inclusion
- Male or female \>18 years of age at time of enrollment.
- The clinical diagnosis of stable plaque psoriasis.
- Two target plaques of similar severity
- ≥ 5 cm2 but ≤ 100 cm2 computed by multiplying the greatest diameter of the plaque by the diameter of the plaque perpendicular to the greatest diameter.
- Bilaterally located (right/left) plaques on the arms or plaques located on the upper and lower trunk. Plaques located on the trunk were to be separated by at least 10 cm and designated by the Investigator as either left/right or front/back.
- Target plaque severity score of 2-4 (mild to moderate).
- Normal or not clinically significant screening laboratory results.
- Subjects who were willing and able to apply study drug as directed, comply with study instructions, and commit to all follow-up visits.
- Subjects who had the ability to understand, agree to and sign the study Informed Consent Form (ICF) prior to initiation of any protocol related procedures.
Exclusion
- Any dermatological conditions that could interfere with clinical evaluations or any disease state or physical condition which might expose the patient to an unacceptable risk by study participation
- Any underlying disease(s) or other dermatological conditions that require the use of exclusionary topical or systemic therapy (see below)
- Known sensitivity to any of the components of the study medication
- Spontaneously improving or rapidly deteriorating psoriatic plaques or pustular/exfoliative, guttate, erythrodermic or other non-plaque form of psoriasis
- Concomitant use of topical or systemic therapies that might alter the course of psoriasis
- Females of child bearing potential. Females must be post-menopausal (based on FSH levels) or surgically sterile (oophorectomy)
- Washout periods of:
- Topical drugs that might alter the course of psoriasis: 2 weeks
- Oral retinoids: 8 weeks
- Non-retinoid systemic drugs that might alter the course of psoriasis: 4 weeks
- PUVA: 4 weeks
- UVB therapy: 4 weeks
- Use of emollients/moisturizers on area(s) to be treated: 2 days prior to baseline visit
- AIDS or AIDS related illness
- Concurrent participation in another drug research study or within 30 days of enrollment
- Use of lithium or hydroxychloroquine containing products (i.e. Plaquenil)
- Use of a beta-blocking medication (i.e. propranolol) if the dose has not been stabilized for at least 3 months
Key Trial Info
Start Date :
November 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2008
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT00759161
Start Date
November 1 2007
End Date
March 1 2008
Last Update
March 6 2017
Active Locations (1)
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1
IMIC
Mexico City, Mexico City, Mexico, 06700