Status:
COMPLETED
Inflammation and Vascular Function in Atherosclerosis
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Atherosclerosis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
The purpose of this study is to determine whether reducing inflammation in blood vessels with an aspirin-like drug called salsalate will improve blood vessel function.
Detailed Description
To test the hypothesis that inhibition of I \[kappa\] B kinase \[beta\] (IĸKβ), an inflammatory mediator, by high dose salsalate, will restore insulin-mediated endothelium-dependent vasodilation in su...
Eligibility Criteria
Inclusion
- Non-smoking adult subjects with known atherosclerosis
Exclusion
- Uncontrolled hypertension (\> 140/90 mmHg)
- Untreated hypercholesterolemia (LDL \> 160 mg/dL)
- Diabetes mellitus
- Alanine Aminotransferase \> 150
- Creatinine \> 1.4 mg/dL
- Concommitant use of warfarin
Key Trial Info
Start Date :
August 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2011
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT00760019
Start Date
August 1 2005
End Date
February 1 2011
Last Update
May 16 2017
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115