Status:
COMPLETED
A Study to Investigate the Anti-Plaque Effect of AN0128 Toothpaste
Lead Sponsor:
Pfizer
Conditions:
Dental Plaque
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
The objective of this study was to evaluate the anti-plaque efficacy of the Anacor prototype dentrifice as compared to commercial control products following a single use of the dentrifice.
Detailed Description
The widespread successful use of triclosan as an anti-inflammatory and anti-bacterial agent is well documented. The standard dentrifice has demonstrated a robust anti-plaque and anti-inflammatory effe...
Eligibility Criteria
Inclusion
- Must be between ages 18 to 65 years inclusive
- Have a minimum of 16 natural uncrowned teeth (excluding 3rd molars) present
- Must give written informed consent
- Be in good general health
- Must discontinue oral hygiene for 24-hours after initial appointment
- No known history of allergy to personal care/consumer products or their ingredients, relevant to any ingredient in the test products as determined by the dental/medical professional monitoring the study
Exclusion
- Medical condition which requires pre-medication prior to dental visits/procedures
- Advanced periodontal disease
- 5 or more decayed, untreated dental sites
- Diseases of the soft or hard oral tissues
- Orthodontic appliances
- Abnormal salivary function
- Use of drugs that can affect salivary flow
- Use of antibiotics one (1) month prior to or during this study
- Use of any over the counter medications other than analgesics (i.e. aspirin, ibuprofen, acetaminophen, naproxen), unless approved by the study medical staff
- Pregnant or breastfeeding
- Participation in another clinical study in the month preceding this study
- Allergic to common dentifrice ingredients
- Immune compromised individuals (HIV, AIDS, immuno suppressive drug therapy)
- History of allergic reaction to any anti-inflammatory agents
Key Trial Info
Start Date :
November 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00762151
Start Date
November 1 2007
End Date
January 1 2008
Last Update
June 5 2019
Active Locations (1)
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1
Concordia Research Laboratories
Cedar Knolls, New Jersey, United States, 07927