Status:
RECRUITING
Circulating Markers for Ischemic Heart Disease
Lead Sponsor:
UConn Health
Conditions:
Myocardial Infarction
Ischemia
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this research is to determine if two proteins in the blood are increased during acute myocardial infarction and whether their levels are higher in those who develop heart failure than t...
Detailed Description
Hypotheses, Objectives and Aims: Hypotheses:Caspase-3, cleaved and activated, and dystrophin can be detected in human circulation. The levels of these two markers are elevated during acute myocardial...
Eligibility Criteria
Inclusion
- men and women, 18 years of age and over with acute myocardial infarction (determined by positive cardiac markers -CKMB/ troponin) with or without heart failure (dyspnea, rales, edema, elevated jugular venous pressure, ascites).
- Heart failure can be diagnosed using imaging evidence such as dilated heart, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures
- A control group of male subjects age 60 and older without history of MI or heart disease
Exclusion
- Subjects unable to give consent
- Subjects who have undergone cardiac or non-cardiac surgery in the 3 months prior to enrollment
Key Trial Info
Start Date :
June 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2027
Estimated Enrollment :
550 Patients enrolled
Trial Details
Trial ID
NCT00762333
Start Date
June 1 2007
End Date
March 1 2027
Last Update
August 12 2025
Active Locations (1)
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1
University of Connecticut Health Center
Farmington, Connecticut, United States, 06030