Status:
TERMINATED
Analysis of Oculo-motor Deficiencies Associated With FMR1 Gene Expression (Genetic Abnormality Predisposing to a Neurodegenerative Disease)
Lead Sponsor:
Nantes University Hospital
Conditions:
Pre-mutation on FMR1 Gene
Eligibility:
MALE
18-50 years
Phase:
NA
Brief Summary
The specific aim of this study is to compare ocular movements abnormalities between males with pre-mutation on FRM1 gene (symptomatic or asymptomatic on the motor plan and/or on the cognitive plan), m...
Detailed Description
Patient will be followed at the Nantes hospital during half a day for : * examination of ocular movements * performing Neuro-psychological test (MATTIS) * performing tests with scales of motricity (U...
Eligibility Criteria
Inclusion
- FOR PATIENTS WITH PREMUTATION ON FMR1 GENE (30 patients expected):
- Inclusion criteria:
- Male
- \> or equal to 50 years old
- Ally second or third degree with a child affected of "fragile X"
- Not living far from Nantes so that visits to the Nantes hospital can be easy
- Pre-mutation on FMR1 gene
- Signed informed consent
- Exclusion criteria:
- Female
- \<50 years old
- visual acuteness \< 1/10
- MATTIS dementia scale \<100 (normal:144)
- Occurrence, shown by MRI (Magnetic Resonance Imaging), of a pathology either ischemic vascular or hemorrhagic or tumoral
- FOR PATIENTS WITHOUT PRE-MUTATION ON FMR1 GENE (10 patients expected):
- Inclusion criteria:
- Male
- \> or equal to 50 years old
- Ally second or third degree with a child affected of "fragile X"
- Not living far from Nantes so that visits to the Nantes hospital can be easy - Signed informed consent
- Exclusion criteria:
- Female
- \<50 years old
- visual acuteness \< 1/10
- MATTIS dementia scale \<100 (normal:144)
- Pre-mutation on FMR1 gene
- Occurrence, shown by MRI, of a pathology either ischemic vascular or hemorrhagic or tumoral
- FOR PATIENTS WITH MULTI-SYSTEMATIZED ATROPHY (10 patients expected):
- Inclusion criteria:
- Male
- \> or equal to 50 years old
- Not living far from Nantes so that visits to the Nantes hospital can be easy
- "probable" diagnosis of multi-systematized atrophy
- Signed informed consent
- Exclusion Criteria:
- Female
- \<50 years old
- visual acuteness \< 1/10
- MATTIS dementia scale \<100 (normal:144)
- Occurrence, shown by MRI, of a pathology either ischemic vascular or hemorrhagic or tumoral
Exclusion
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2009
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT00763191
Start Date
June 1 2008
End Date
September 1 2009
Last Update
December 10 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Laennec hospital, university hospital of Nantes
Nantes, France, 44093