Status:
COMPLETED
Randomized, Double-blind Safety and Efficacy Study of Lisdexamfetamine Dimesylate (LDX) in Children and Adolescents Aged 6-17
Lead Sponsor:
Shire
Conditions:
ADHD
Eligibility:
All Genders
6-17 years
Phase:
PHASE3
Brief Summary
The main aim of this study is to see if giving LDX to children and adolescents aged 6-17 years with ADHD decreases symptoms of ADHD.
Eligibility Criteria
Inclusion
- Subject is a male or female aged 6-17 years inclusive at the time of consent.
- Subject must meet Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition - Text Revision (DSM-IV-TR) criteria for a primary diagnosis of ADHD based on a detailed psychiatric evaluation.
- Subject must have a Baseline ADHD-RS-IV total score ≥28.
- Subject has blood pressure measurements within the 95th percentile for age, gender, and height at Screening and Baseline.
- Subject is able to swallow a capsule.
Exclusion
- Subject has failed to respond to more than one adequate course (dose and duration) of stimulant therapy. One course must have been a long-acting formulation.
- Subject has a conduct disorder. Oppositional Defiant Disorder is not exclusionary.
- Subject is currently considered a suicide risk, has previously made a suicide attempt or has a prior history of, or is currently, demonstrating active suicidal ideation.
- Subject has glaucoma.
- Subject weighs less than 22.7kg (50lbs).
- Subject is significantly overweight based on Centre for Disease Control and Prevention Body Mass Index (BMI)-for-age gender specific charts at Screening. Significantly overweight is defined as a BMI \>97th percentile for this study.
- Subject has a documented allergy, hypersensitivity, or intolerance to amphetamine or methylphenidate.
- Subject has a documented allergy, hypersensitivity, or intolerance to any excipients in the test or reference products.
- Subject has a history of seizures (other than infantile febrile seizures), a tic disorder, or a current diagnosis and/or a known family history of Tourette's Disorder.
- Subject has a known history of symptomatic cardiovascular disease, advance arteriosclerosis, structural cardiac abnormality, cardiomyopathy, serious heart rhythm abnormalities, coronary artery disease, or other serious cardiac problems that may place them at increased vulnerability to the sympathomimetic effects of a stimulant drug.
- Subject has a known family history of sudden cardiac death or ventricular arrhythmia.
- Subject is well controlled on their current ADHD medication with acceptable tolerability.
- Subject has a pre-existing severe gastrointestinal tract narrowing (pathologic or iatrogenic).
Key Trial Info
Start Date :
November 17 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 16 2011
Estimated Enrollment :
336 Patients enrolled
Trial Details
Trial ID
NCT00763971
Start Date
November 17 2008
End Date
March 16 2011
Last Update
June 14 2021
Active Locations (49)
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1
ZiekenhuisNetwerk Antwerpen, Commandant Weynsstraat 165, Campus Hoge Beuken
Hoboken, Antwerp, Belgium, 2660
2
Universitair Ziekenhuis Gent, Kinder-en Jeugdpsychiatrie, De Pintelaan 185
Ghent, East Flanders, Belgium, 9000
3
Afdeling Psychiatrie, UZ Herestraat 49, Bus 07003
Leuven, Belgium, 3000
4
Hospital Archet 2
Nice, Cedex 03, France, 6202