Status:
UNKNOWN
Cardiovascular Phenotype Study in Patients With Obstructive Sleep Apnea Syndrome
Lead Sponsor:
University Hospital, Grenoble
Conditions:
Obstructive Sleep Apnea Syndrome
Hypertension
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
Patients with obstructive sleep apnea syndrome have permanent variations of their hemodynamic parameters during the night : heart rate, arterial blood pressure, cardiac output. This is due to the repe...
Detailed Description
Objective of the study is to characterize the cardiovascular phenotype of patients with obstructive sleep apnea syndrome, relative to the presence of hypertension or not. Hypertension should not have ...
Eligibility Criteria
Inclusion
- patients with or without obstructive sleep apnea syndrome (AHI \> 15)
- patients with or without hypertension
Exclusion
- known or expected secondary hypertension
- pathologies with consequences on arterial blood pressure regulation: Parkinson's disease, patients with renal or cardiac graft, severe heart failure
- drugs with consequences on arterial blood pressure regulation : vasoconstrictors, vasodilatators, béta-agonists, antagonists, nitrites, theophylline, dipyridamol, sildenafil, immunosuppressors, IMAO, neuroleptics, tricyclic antidepressants, corticoids or long-term oral (\>10 days) non steroidal anti-inflammatory drugs, oestroprogestative treatments
- atrial fibrillation, frequent extrasystoles (\> or = to 10/minute)
- bedridden patients
- night shift workers
- surgical or carotid stenting history
- subjects unwilling or unable to provide written, signed and dated informed consent
- patient previously treated for obstructive sleep apnea syndrome (positive airway pressure, forward mandible prosthesis, maxillofacial surgery
Key Trial Info
Start Date :
March 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2008
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00764218
Start Date
March 1 2001
End Date
December 1 2008
Last Update
October 1 2008
Active Locations (1)
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1
Cardiology and hypertension service
Grenoble, Isère, France, 38000