Status:
COMPLETED
Aerobic and Strengthening Exercise for Acute Leukemia
Lead Sponsor:
St. Jude Children's Research Hospital
Conditions:
Acute Lymphoblastic Leukemia
Eligibility:
All Genders
5-10 years
Phase:
NA
Brief Summary
Survivors of childhood leukemia have muscle weakness and impaired mobility (physical performance), a higher than expected frequency of obesity, and early mortality from cardiovascular disease. Treatme...
Detailed Description
The purpose of this trial is to determine the feasibility of an aerobic and strengthening exercise intervention trial among children during maintenance therapy for childhood ALL by evaluating particip...
Eligibility Criteria
Inclusion
- Diagnosed with childhood ALL when age greater than 1 and less than 10 at diagnosis, white blood cell count less than 50,000 cells/microliter and receiving continuation/maintenance therapy based on the original disease classification
- In first remission
- Maintenance phase of therapy (Eligibility extends from Day 0 of maintenance therapy up to six months prior to the completion of therapy)
- Current age 5-10 years
- Modified Lansky performance scale must score 60 or higher at time of enrollment
- Written informed consent
Exclusion
- Lower extremity amputation or congenital deformity of lower limb
- History of pre-existing neuron-motor or neuro-developmental disorder prior to diagnosis of childhood ALL, such as mental retardation, Down syndrome, cerebral palsy, and traumatic brain injury
- Pre-existing heart or lung disease by clinical history
- Children with specific contraindications to exercise will be offered enrollment after this transient condition is resolved: severe anemia (Hemoglobin less than 8 g/dl), fever greater than 38 degrees Centigrade, platelets less than 50\*109/ul, neutrophil counts less than 0.5\*109/ul.
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00766311
Start Date
January 1 2008
End Date
December 1 2011
Last Update
January 9 2012
Active Locations (4)
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1
Oregon Health and Science University
Portland, Oregon, United States, 97239
2
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
3
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
4
Vanderbilt Ingram Cancer Center
Nashville, Tennessee, United States, 37215