Status:
COMPLETED
Platelet Hyperreactivity to Aspirin and Stroke
Lead Sponsor:
University of Sao Paulo
Collaborating Sponsors:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Accumetrics, Inc.
Conditions:
Stroke
Cerebral Infarction
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
STUDY QUESTIONS * What is the real prevalence of platelet "resistance" to aspirin during the acute phase of stroke and after 3 months, and 1 year, as measured using different platelet function tests?...
Detailed Description
THE CONTEXT Aspirin is the anti-thrombotic therapy of choice for patients in the acute or chronic phase of vascular, cardiac, and neurological diseases, unless there is a specific indication for sodi...
Eligibility Criteria
Inclusion
- Consecutive patients with the diagnosis of ischemic stroke in the acute phase who will be treated with aspirin for an indefinite period
Exclusion
- The need for full anticoagulation therapy for pulmonary embolism, deep vein thrombosis, chronic atrial fibrillation, thrombus in the left atrium or left ventricle, or for any other reason deemed relevant by the patient's physician
- Thrombolytic treatment for stroke
- History of allergy to aspirin (hives, swelling of glottis or anaphylaxis)
- Risk of excessive bleeding due to active peptic ulcers, liver failure, history of bleeding or bleeding diathesis
- Scheduled major or vascular surgery
- Metastatic cancer or survival estimated at less than a year
- Creatinine clearance below 30 mL/min
- Platelet count \<100,000/mm3
- Hematocrit \<30%
- Lipaemic blood
- Difficult follow-up: patients with serious social problems, alcoholics, and residents of other states in the country
- Refusal to participate in the study
Key Trial Info
Start Date :
July 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2013
Estimated Enrollment :
203 Patients enrolled
Trial Details
Trial ID
NCT00766896
Start Date
July 1 2009
End Date
June 1 2013
Last Update
June 24 2013
Active Locations (1)
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1
University of Sao Paulo, School of Medicine
São Paulo, São Paulo, Brazil, 05403000