Status:
COMPLETED
Persantin Preceding Elective PCI
Lead Sponsor:
Radboud University Medical Center
Conditions:
Coronary Heart Disease
Percutaneous Transluminal Coronary Angioplasty
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
In this study the investigators will investigate whether a short pretreatment (3-7 days) with dipyridamole 200mg twice daily will protect patients against myocardial injury sustained during an electiv...
Detailed Description
Rationale: In elective PCI (percutaneous coronary intervention) up to 40% of the patients show an asymptomatic rise in myonecrosis marker troponin-I. This release of troponin-I has been found to repr...
Eligibility Criteria
Inclusion
- Patients accepted for elective single, native vessel (left anterior descending, right coronary artery or ramus circumflexus (LAD, RCA or RCX)) PCI in the RUNMC
- Troponin-I \< 0,20 mmol/L at screening
- Signed Informed consent
Exclusion
- unstable angina
- recent myocardial infarction (STEMI or non-STEMI), during two weeks prior to inclusion
- 3-Vessel disease as seen on coronary angiogram
- Stenotic lesion in main stem as seen on coronary angiogram
- CABG in medical history
- asthma (recurrent episodes of dyspnoea and wheezing, or usage of prescribed inhalation medication: i.e. corticosteroids or B2-agonists)
- Treatment with insulin
- Use of prescribed oral anticoagulants (coumarin derivates)
- Use of oral corticosteroids
- Use of sulfonylurea derivates (glibenclamide, tolbutamide, gliclazide, glimepiride)
- Use of heparin or low molecular weight heparin
- Use of metformin
- Use of dipyridamole
- Chronic use of Non Steroid Anti-Inflammatory Drugs (NSAID's)
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00767663
Start Date
October 1 2008
End Date
February 1 2010
Last Update
October 30 2015
Active Locations (2)
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1
RUNMC
Nijmegen, Netherlands, 6500HB
2
Canisius Wilhelmina Hospital
Nijmegen, Netherlands, 6532SZ