Status:
COMPLETED
Toll-like Receptor 2 Gene Polymorphism, Serum Cytokines and Susceptibility to Disease Severity or Treatment Response of Pulmonary Tuberculosis
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
Pulmonary Tuberculosis
Genetic Variants of Host
Eligibility:
All Genders
20-90 years
Brief Summary
Infection with Mycobacterium tuberculosis remains at epidemic levels globally. Innate and adaptive immune responses evolve as protective mechanisms against mycobacterial infection in humans. Toll-like...
Detailed Description
Infection with Mycobacterium tuberculosis (TB) remains at epidemic levels globally. One third of the word's population is infected with this organism, making tuberculosis the most prevalent infectious...
Eligibility Criteria
Inclusion
- a) findings on CXR that are compatible with presentations of Mycobacterium tuberculosis b) clinical symptoms, such as fever, body weight loss, night sweating, chest pain and chronic cough, that indicate active infection of pulmonary tuberculosis (TB) c) microbiological diagnosis by sputum smear and culture, bronchoalveolar lavage fluid culture, or DNA probe examination.
- d) Resolution on CXR with anti-TB regimens e) Written informed consent form prior to participation into this study
Exclusion
- a) concurrent active disease of other chronic illnesses, such as lung cancer, chronic bronchitis and bronchial asthma b) poor physical conditions that make any examination infeasible c) participation in another trial with use of an investigated drug within on month d) use of corticosteroid or immunosuppressant drugs
Key Trial Info
Start Date :
August 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2009
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00772408
Start Date
August 1 2006
End Date
November 1 2009
Last Update
February 28 2013
Active Locations (2)
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1
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung Hsien, Taiwan, Taiwan, 886
2
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung, Taiwan, Taiwan, 886