Status:
COMPLETED
A Feasibility Trial of Avastin (Bevacizumab) in Combination With Concomitant Chemoradiation (Cisplatin and Vinorelbine) in Patients With Locally Advanced Non-Squamous Non-Small Cell Lung Cancer.
Lead Sponsor:
Hoffmann-La Roche
Conditions:
Non-Squamous Non-Small Cell Lung Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
This single arm study will assess the feasibility of use, safety and tolerability of Avastin(bevacizumab) in combination with chemoradiation therapy in patients with locally advanced unresectable non-...
Eligibility Criteria
Inclusion
- patients \>=18 years with locoregional advanced unresectable non-squamous NSCLC;
- ECOG performance status of 0 or 1;
- no prior thoracic head and neck irradiation or surgical resection for current lung cancer.
Exclusion
- mixed, non-small cell and small cell tumors;
- mixed adeno-squamous carcinomas with a predominant squamous component;
- evidence of tumor invasion or encasement of major vessels;
- history of grade \>=2 hemoptysis;
- presence of cavitations in lung lesions at baseline.
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT00773188
Start Date
December 1 2008
End Date
October 1 2010
Last Update
November 2 2016
Active Locations (4)
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1
Calgary, Alberta, Canada, T2N 4N2
2
Oshawa, Ontario, Canada, L1G 2B9
3
Ottawa, Ontario, Canada, K1H 8L6
4
Toronto, Ontario, Canada, M4N 3M5