Status:
COMPLETED
Genomic Imprinting and Assisted Reproductive Technologies
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Natural Pregnancy
Pregnancy, Ovarian
Eligibility:
FEMALE
26-40 years
Brief Summary
Genomic imprinting, referring to an epigenetic marking resulting in monoallelic gene expression, plays a critical role in development. Recently, various imprinting diseases were reported in animals (L...
Detailed Description
Methodology: assessment of the methylation status at 9 different imprinted loci (using Southern blot and methyl-specific quantitative PCR) in 3 groups of patients: 150 children naturally conceived, 15...
Eligibility Criteria
Inclusion
- Mother :
- Age: 26 to 40 at conception
- Single foetus pregnancy
- Signed informed consent
- Affiliation to French health benefits
- Absence of maternal pathology
- Normal foetal karyotype (if available)
- Known procedure of ovarian stimulation
- ART procedure without sperm or oocyte donation
- ART in a participating ART departments
- Delivery in a participating hospital
- Father
- Age : 18 to 50 at conception
- Signed informed consent
Exclusion
- Abnormal foetal karyotype (if available)
- Delivery before 35 weeks of amenorrhea
- Delivery in not participating hospital
- Delivery complication leading to the absence of sample collection
Key Trial Info
Start Date :
February 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2015
Estimated Enrollment :
542 Patients enrolled
Trial Details
Trial ID
NCT00773825
Start Date
February 1 2007
End Date
June 1 2015
Last Update
June 18 2015
Active Locations (1)
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1
Trousseau Hospital
Paris, France, 75012