Status:
UNKNOWN
Characterization of Bronchiolitis-obliterans Syndrome (BOS) Following Lung Transplantation
Lead Sponsor:
Hannover Medical School
Conditions:
Lung Transplantation
Bronchiolitis Obliterans Syndrome
Eligibility:
All Genders
18-68 years
Brief Summary
Chronic organ dysfunction after lung transplantation (BOS) is the most common cause of death in long-term survivors after lung transplantation and refractory to most interventions. Early markers will ...
Detailed Description
Chronic organ dysfunction of the lung allograft is the most common cause of death in lung transplant recipients after the first postoperative year and is a major cause of morbidity in the long-term ca...
Eligibility Criteria
Inclusion
- Individuals, who have undergone double (DLTx) or heart and lung transplantation (HLTx) at Hannover Medical School 6 months prior to inclusion
- Ages: 18 to 68 Years
- Gender: both
- Stable graft function (FEV1 \>90% baseline)
Exclusion
- Severe airway complications after surgery necessitating repeated intervention during the last 3 months
- Need for supplemental oxygen at time of inclusion
- Single lung (SLTx) and living lobar recipients
- Established diagnosis of BOS at time of inclusion
- Inability to undergo bodyphlethysmography e.g. due to persistent infection with multi-drug resistant bacteria (MRSA, VRE, Burkholderia Cepacia, Pandorea)
Key Trial Info
Start Date :
July 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2014
Estimated Enrollment :
261 Patients enrolled
Trial Details
Trial ID
NCT00774449
Start Date
July 1 2009
End Date
June 1 2014
Last Update
July 21 2011
Active Locations (1)
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1
Department of Respiratory Medicine, Medizinische Hochschule Hannover
Hanover, Germany, 30625