Status:
COMPLETED
Karolinska-Rennes (KaRen) Prospective Study of Exercise Stress Echocardiography in Heart Failure With Preserved Ejection Fraction
Lead Sponsor:
French Cardiology Society
Collaborating Sponsors:
Fédération Française de Cardiologie
Conditions:
Heart Failure
Eligibility:
All Genders
18+ years
Brief Summary
Background: Heart failure with preserved ejection fraction (HFPEF) is common but not well understood. Electrical dyssynchrony in systolic heart failure is harmful. Little is known about the prevalenc...
Eligibility Criteria
Inclusion
- Acute presentation to the hospital with clinical signs and symptoms of HF, according to the Framingham criteria \[19\].
- LVEF ≥ 45% by echocardiography within the first 72 hours. The measurement will be carried out according to guidelines
- BNP \>100 ng/L or NT-proBNP \>300 ng/L.
Exclusion
- Evidence of primary hypertrophic or restrictive cardiomyopathy or systemic illness known to be associated with infiltrative heart disease
- Known cause of right heart failure not related to left ventricular dysfunction
- Pericardial constriction
- Clinically significant pulmonary disease, as evidenced by requirement of current home oxygen
- End-stage renal disease currently requiring dialysis
- Bi-ventricular pacemaker (CRT). (Patients who have a conventional pacemaker may be included)
- Anticipated or indication for cardiac surgery. (Patients who have indication for surgery but may not undergo surgery because of some contraindication, for example age, may NOT be included).
- Anticipated percutaneous intervention on aortic stenosis. (Patients who undergo other percutaneous intervention, for example PCI, may be included).
Key Trial Info
Start Date :
October 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00774709
Start Date
October 1 2008
End Date
November 1 2012
Last Update
September 30 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Service de Cardiologie et CIT-IC 804, LTSI INSERM U 642
Rennes, France, 35033