Status:
TERMINATED
Characterization of Brachial Arterial t-PA Release, Endothelial Function, Obesity and Inflammation
Lead Sponsor:
Vanderbilt University
Conditions:
Obesity
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
T-PA release is impaired in obese subjects. In order to have a better mechanistic understanding of t-PA release, we will compare t-PA release to Flow Mediated Vasodilation, Radial Artery Tonometry, an...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Adults 18 years and greater
- Healthy
- Exclusion criteria:
- PVC \< 30
- Hypertensive subjects on ACE inhibitors
- Pregnant or nursing mothers
- Diabetic with HbA1C \> 7.5 or stigmata of end organ damage (neuropathy, retinopathy, nephropathy, cardiomyopathy)
- Cholesterol \> 30 mg/dL above NCEP accepted level based on cardiac risk.
- Triglycerides \> 200
- Previously diagnosed obstructive coronary artery disease, myocardial infarction or left ventricular dysfunction (with or without a history of congestive heart failure)
- Renal insufficiency (Creatinine ≥ 1.5 mg/dl)
- History of cerebrovascular disease
- Any chronic inflammatory disease (rheumatologic, inflammatory bowel disease, etc)
- Uncontrolled Stage 2 Hypertension (160/100 mmHg), or end organ damage due to hypertension (left ventricular hypertrophy, atrial fibrillation, hematuria, renal insufficiency, prior cerebrovascular disease).
- Angiotensin converting enzyme inhibitor use
- Coagulopathy (INR ≥ 1.5, PTT ≥ 1.5 x control)
- Other chronic medical illnesses at the discretion of the investigators
Exclusion
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2011
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT00780481
Start Date
January 1 2007
End Date
May 1 2011
Last Update
July 14 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232