Status:
UNKNOWN
The Role of Posterior Fossa Irradiation (PFI) Plus Stereotactic Radiosurgery (SRS) for Cerebellar Metastases
Lead Sponsor:
Tel-Aviv Sourasky Medical Center
Conditions:
Neoplasm Metastasis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The aggregate of data pertaining to brain metastases suggests that optimal results are achievable with a 2-pronged approach that addresses both the specific focus (with surgery or radiosurgery) and th...
Detailed Description
SCHEMA: * Posterior Fossa Irradiation as defined by diagnostic MRI and CT simulation. * 37.5 Gy in 2.5 Gy fractions administered via conformal beams. * Radiosurgical boost (with dose titrated to para...
Eligibility Criteria
Inclusion
- Histologically confirmed malignant disease
- All primary tumors exclusive of:
- Small cell lung cancer
- Renal cell cancer (hypernephroma)
- Melanoma
- Sarcoma
- 1-3 intraparenchymal metastases
- Age ≥18 years
- RPA(14) 1 or 2
- Patients who have undergone resection are eligible provided residual disease is evident on imaging
- No clinical or radiographic evidence of progression of extracranial disease in month prior to enrollment on study.
Exclusion
- Major psychiatric illness
- Lesions in brainstem, midbrain, pons, medulla
- Patient who have undergone complete resection of all known infratentorial disease
- Patients with leptomeningeal metastases
- Patients with hepatic metastases
- Patients with metastases from the following primary tumors are ineligible: Small Cell Lung Cancer; rena Cell Carcinoma; Melanoma; Sarcoma
- Previous cranial irradiation
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2010
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00781209
Start Date
October 1 2008
End Date
December 1 2010
Last Update
October 28 2008
Active Locations (1)
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1
Radiotherapy Department, TASMC
Tel Aviv, Israel, 64239