Status:
COMPLETED
Effects of Viagra on Heart Function in Patients With Heart Failure
Lead Sponsor:
MetroHealth Medical Center
Collaborating Sponsors:
National Center for Research Resources (NCRR)
Conditions:
Heart Failure
Left Ventricular Dysfunction
Eligibility:
All Genders
25-75 years
Phase:
PHASE4
Brief Summary
Sildenafil (Viagra) is known to reduce pulmonary hypertension. Heart failure patients also have pulmonary hypertension and several recent reports have shown that sildenafil leads to an improvement in ...
Detailed Description
Sildenafil (Viagra) has been extensively studied in patients with idiopathic pulmonary hypertension. It reduces pulmonary vascular resistance, improves exercise capacity and is now an approved therapy...
Eligibility Criteria
Inclusion
- Adults with Class III congestive heart failure and impaired left ventricular systolic function.
- A prior BNP level ≥ 200 pg/mL.
- Previously documented systolic pulmonary artery pressure \>40 mmHg.
- Clinically stable for a minimum of 6 weeks.
- Able to give informed consent,
Exclusion
- Unable to give informed consent.
- Currently taking nitrates.
- A HF exacerbation within the past 6 weeks.
- Co-morbid conditions that could limit their walking.
- Have a resting systolic blood pressure \< 110 mmHg
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2009
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00781508
Start Date
December 1 2006
End Date
November 1 2009
Last Update
July 2 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
MetroHealth Medical Center
Cleveland, Ohio, United States, 44109