Status:
COMPLETED
Using Neuroimaging to Investigate Major Depressive Disorder
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Major Depressive Disorder
Depression
Eligibility:
All Genders
18-50 years
Brief Summary
The purpose of this neuroimaging study is to investigate the brain correlates of Major Depressive Disorder with anxiety symptoms as well as potentially identify predictors of treatment outcome.
Detailed Description
The purpose of this study is to test whether the structural and functional connectivity between the dorso-lateral prefrontal cortex (DLPFC) and amygdala will decline as symptoms of co-morbid anxiety (...
Eligibility Criteria
Inclusion
- Competent to give informed consent
- Diagnosis of Major Depressive Disorder
- Males and females
- Ages 18-50 years old
- All races and ethnicities
- Able to read, speak, and understand English\*
Exclusion
- History of psychiatric illness except Major Depressive Disorder, Generalized Anxiety Disorder, Social Phobia, or Specific Phobia
- Alcohol or substance abuse within the last 6 months or alcohol or substance dependence within the last year
- Diagnosis of an organic brain disease
- Serious unstable medical illness
- History of serious head injury
- Unsafe or unable to have an MRI or previous inability to tolerate MRI
- Pregnancy or breast feeding
Key Trial Info
Start Date :
May 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 20 2011
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT00781677
Start Date
May 1 2008
End Date
January 20 2011
Last Update
February 6 2019
Active Locations (1)
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1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390