Status:
COMPLETED
Mesenchymal Stem Cells for the Treatment of MS
Lead Sponsor:
Hadassah Medical Organization
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
35-65 years
Phase:
PHASE1
PHASE2
Brief Summary
Although, effective immunotherapies for MS exist which downregulate the anti-myelin reactivity and reduce the rate of relapses of the disease, there is no effective means today to stop the progression...
Detailed Description
This study, is designed as a phase 1/2 open-safety clinical trial. At its first phase, 15 consenting patients with MS are included. Inclusion Criteria: Consenting patients fulfilled the following 4 ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Consenting patients fulfilling the Poser's clinical criteria for definite MS
- Age: 35-65, males and females
- Duration of disease: \>5 years
- Failure to the currently available -registered- for MS immunomodulatory treatments (ie interferons, Copaxone, immunosuppression): the lack of response to (at least two) of these treatments will be determined/defined by either an increase (deterioration) of at least one degree in the EDSS score during the last year or the appearance of at least two major relapses of MS during the same period of time (under treatment).
- Exclusion criteria
- Patients who were treated with cytotoxic medications (cyclophosphamide, Mitoxanthrobne etc) during the last 3 months prior to the inclusion
- Patients suffering from significant cardiac, renal or hepatic failure or any other disease that may risk the patient or interfere with the ability to interpret the results
- Patients with active infections
- Patients with severe cognitive decline or inability to understand and sign the informed consent
Exclusion
Key Trial Info
Start Date :
October 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00781872
Start Date
October 1 2006
End Date
December 1 2009
Last Update
March 29 2021
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.