Status:
COMPLETED
Apneic Oxygenation Via Nasal Cannulae Prevents Arterial Hypoxemia
Lead Sponsor:
University of Manitoba
Conditions:
Hypoxia
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of the study is to evaluate the effectiveness of continuous oxygen provided by nasal prongs in preventing or delaying hypoxemia during the apneic period that occurs after induction of gene...
Detailed Description
Certain patient populations are at risk for rapid desaturation and the rapid development of hypoxemia (eg. morbidly obese and pregnant patients). Using pulse oximetry, it has already been shown that o...
Eligibility Criteria
Inclusion
- Healthy males and females
- ASA Class 1-3
- Ages of 18 to 65
- Elective surgery under general anesthesia
- No evidence of significant cardiac, respiratory or gastrointestinal disease
- No contraindications to the insertion of a radial arterial catheter
Exclusion
- Evidence of a difficult airway (expected difficult intubation identified from patient history or clinical examination)
- Features suggestive of difficult bag mask ventilation
- Significant GERD requiring medical therapy
- Significant respiratory disease (including severe asthma or COPD, oxygen dependency, pulmonary hypertension)
- Significant cardiac disease (ischemic heart disease, severe aortic and mitral stenosis and/or regurgitation, EF \< 50% if known)
- Inability to lie flat (skeletal deformities, orthopnea, congestive cardiac failure)
- PaO2 \< 200 mmHg on ABG after adequate preoxygenation to an ETO2 \> 85%
- Hemoglobin \< 100 g/L
- BMI \> 40 kg/ m2
- Pregnancy
- Patient unwillingness or refusal to participate
- Inability to consent (dementia) or cooperate (mentally challenged)
- Inability to communicate well or to understand English (language barrier, dysphasia)
- Neuromuscular disorders
- Known or presumed cervical spine instability (cervical spine fractures, rheumatoid arthritis)
- Patients undergoing neurosurgical procedures
- Any clinical or radiological evidence of increase in intracranial pressure
- Any requirement for rapid sequence intubation
- Inability to tolerate the apneic period
- Allergy to any of the agents used for induction of general anesthesia in the study
- Arterial insufficiency with poor collateral circulation to the hand (tested with Doppler ultrasound or clinically by palpation with the Allen test)
- Inability to cannulate an artery for monitoring and sampling purposes
- Uncorrected coagulopathy
- Baseline hypercarbia (PaCO2 \> 50 mmHg)
- Known or suspected obstructive sleep apnea
- Significant nasal obstruction
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2012
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00782977
Start Date
November 1 2008
End Date
December 1 2012
Last Update
December 20 2012
Active Locations (1)
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1
St. Boniface General Hospital
Winnipeg, Manitoba, Canada, R2H 2A6