Status:
COMPLETED
Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Negative Symptoms in Schizophrenia
Lead Sponsor:
Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH
Collaborating Sponsors:
University of Göttingen
Conditions:
Schizophrenia
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Schizophrenia is a major psychotic disorder that presents an enormous burden to the patients and their relatives. Despite treatment with second generation antipsychotics, negative symptoms and cogniti...
Eligibility Criteria
Inclusion
- Male or female in-patients and out-patients, 18 - 60 years of age
- Diagnostic criteria for schizophrenia according to ICD-10/DSM IV
- PANSS negative sum score \> 20 points, 1 of items N1 - N7 (range 1 to 7) ≥ 4 (at least moderate)
- Improvement in PANSS negative sum score less than 10 % in the last 2 weeks prior to study entry, stable antipsychotic medication
- Informed Consent
Exclusion
- Clinically relevant psychiatric comorbidity, verbal IQ \< 85
- History of epileptic seizures, organic brain disease
- Instable medical comorbidity or condition
- Previous treatment by rTMS
- Factors not compatible with the use of TMS, e.g. cardiac pace makers or other metallic implants, pregnancy
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
197 Patients enrolled
Trial Details
Trial ID
NCT00783120
Start Date
January 1 2008
End Date
December 1 2011
Last Update
November 4 2013
Active Locations (3)
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1
Department of Psychiatry and Psychotherapy, University of Regensburg
Regensburg, Bavaria, Germany, 93053
2
Dept. of Psychiatry and Psychotherapy, University Hospital of the Georg-August-University Göttingen
Göttingen, Lower Saxony, Germany, 37075
3
Department of Psychiatry, Heinrich-Heine University Hospital
Düsseldorf, North Rhine-Westphalia, Germany, 40629