Status:
TERMINATED
Opioid Growth Factor (OGF) and Gemcitabine: Novel Treatment for Pancreatic Cancer
Lead Sponsor:
Milton S. Hershey Medical Center
Collaborating Sponsors:
National Institutes of Health (NIH)
National Cancer Institute (NCI)
Conditions:
Pancreatic Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
It is hypothesized that OGF biotherapy may be safely administered in combination with gemcitabine to individuals with unresectable pancreatic cancer. The study includes two aims, the first is to evalu...
Detailed Description
Pancreatic cancer is the 4th leading cause of cancer-related deaths in the United States with a median survival of 3-6 months and a five-year survival rate of 1% making it the worse of all gastrointes...
Eligibility Criteria
Inclusion
- unresectable and histological or cytological confirmation of adenocarcinoma of the pancreas and measurable disease by CT scan
- patient has not been previously treated for pancreatic cancer
Exclusion
- history of cancer other than pancreatic cancer (excluding resected basal cell skin cancer or curative stage 1 cervical cancer if disease free for 5 years or more)
- previous treatment with chemotherapy for pancreatic cancer
- uncontrolled cardiovascular disease (congestive heart failure, symptoms of coronary artery disease, cardiac arrhythmias)
- suffered from myocardial infarction in preceding 6 months
- poorly controlled medical conditions including: asthma, chronic obstructive pulmonary disease, diabetes, seizure disorders, known brain metastases, hepatic or renal failure
- pregnant or nursing women
- known allergy to gemcitabine
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2011
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT00783172
Start Date
January 1 2009
End Date
October 1 2011
Last Update
September 6 2018
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Lehigh Valley Hospital and Health Network
Allentown, Pennsylvania, United States, 18103
2
Penn State Hershey Medical Center
Hershey, Pennsylvania, United States, 17033