Status:
COMPLETED
Sickle Cell Disease and Endothelial Progenitor Cells (EPCs)
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Sickle Cell Anemia
Eligibility:
All Genders
18+ years
Brief Summary
Sickle Cell Disease (SCD) is the most prevalent genetic disease of haemoglobin.The underlying abnormality in the red blood cell (RBC) of SCD is the presence of abnormal sickle cell hemoglobin (HbS), w...
Detailed Description
In the bone marrow, a reservoir of EPCs does exist, which can be mobilized into circulation when needed, for example during ischemia, a situation which may occur in sickle cells disease. These cells a...
Eligibility Criteria
Inclusion
- Age between 18 and 45 yo
- SS genotype if patient
- Absence of relative with sickle cell anemia if healthy volunteer.
- Affiliated to the national health insurance benefit
- Signature of Informed consent form
- oral contraceptive regiment with micro or mini estro-progestative (women)
Exclusion
- present or past (or interrupted for less than 3 months) therapy with hydroxyurea
- Present or recent blood transfusion and/or exchange (in the past 3 months)
- SC genotype (patients)- BMI \> 30 kg/m2
- Positive serodiagnosis for HIV, HVB, HVC
- Know allergy to fluorescein (patients)
- Hemoglobin \< 7.5 g/dL
- Pregnancy confirmed by Beta-HCG test in plasma
- Menopause
- Extreme difficulty for adequate venous puncture
- Smoking for the last month.
- ALAT or ASAT \> 2 x N
- Hypercholesterolemia (cholesterol total \> 2.,2g/L or 6.55 mmol/L),
- Treatment by statin
- Diabetes (fasting blood glucose level equal or superior to 6,1 mmol/L)
- Hypertension (systolic blood pressure \> 140 mmHg or diastolic blood pressure \> 90 mmHg).
Key Trial Info
Start Date :
November 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2009
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT00783627
Start Date
November 1 2006
End Date
November 1 2009
Last Update
February 23 2011
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hopital Tenon, Assistance Publique Hôpitaux de Paris
Paris, France, 75020