Status:
COMPLETED
Using Transcranial Direct Current Stimulation (tDCS) to Enhance the Benefit of Movement Training in Stoke Patients
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Stroke
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
This study will determine if electrical brain stimulation during movement practice can improve the ability of stroke patients to reach for objects more than movement practice alone. People between 18...
Detailed Description
Individuals who have suffered a stroke may benefit from the development of new rehabilitative interventions that can improve motor recovery after a stroke. Objective: The objective of this protocol ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age between 18 and 85 years.
- Ability to sit and be active for an hour on a chair (or wheelchair) without cardiac, respiratory and/or pain disturbances as assessed during the screening visit.
- Willingness to commit to participate in the long-term follow-up study (up to 3 months)
- Willingness to give written informed consent.
- Diagnosis of a first clinically apparent unilateral cortical or subcortical stroke at least 3 months prior to study entry
- EXCLUSION CRITERIA:
- History of severe neurological illness (e.g. brain tumor, epilepsy or acute seizures, polyneuropathy etc.) or severe cognitive impairment (MMSE less than 23)
- MRI contraindications. (Cardiac pacemakers; Intracardiac lines; Implanted medication pumps; Neural stimulators; blood vessel, cochlear, or eye implants; Metal in the cranium except in the mouth; Dental braces; Metal fragments from occupational exposure; Surgical clips in or near the brain).
- History of alcohol or drug abuse
- Active depression of any severity with psychoactive medication changes in the last 2 months, active psychosis, disruptive or violent behavior, poor motivational capacity as assessed by the study physician by patient questioning
- Aphasia or language disturbances that would interfere with performing the study tasks
- Uncontrolled medical problems (e.g., active cancer or renal disease, any type of end-stage pulmonary or cardiovascular disease, diabetes, or other medical conditions, as determined by the study physician, that would interfere with participation in this study).
- Increased intracranial pressure as evaluated by clinical means (fundoscopic exam).
- Severe neglect or ataxia that would interfere in the completion of the study tasks.
- History of more than one stroke or a stroke that affects both sides of the brain, the brainstem, or the cerebellum.
- Inflammation of the tissue, severe rheumatoid arthritis, or abnormal function of the joints due to arthritis in the affected arm used most often.
- Pregnancy
Exclusion
Key Trial Info
Start Date :
October 29 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 24 2011
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00783913
Start Date
October 29 2008
End Date
October 24 2011
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892