Status:
COMPLETED
Effects of Aerobic Exercise in Parkinson's Disease
Lead Sponsor:
US Department of Veterans Affairs
Collaborating Sponsors:
University of Iowa
Conditions:
Parkinson Disease
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
Motivated by reported improvements in aerobic fitness and executive functions after a 6-month aerobic walking intervention in normal sedentary elderly, we conducted a Phase I/II study to investigate e...
Detailed Description
Participants: The participants were recruited in Spring 2009, 2010, and 2011 through regional newspaper advertisements and solicitations in the Movement Disorders Clinic at the University of Iowa and...
Eligibility Criteria
Inclusion
- Veteran or non-veteran;
- Presence of all 3 cardinal features of Parkinson's disease (resting tremor, bradykinesia, and rigidity), which have to be asymmetrical;
- Hoehn and Yahr Scale stage I-III;
- Men or women aged 50-80 capable of performing the planned exercise programs;
- Intention to remain in the local area over the study period;
- Stable dopaminergic treatment regimen for at least 4 weeks prior to baseline without any clinical need for medication adjustment at the time of screening
Exclusion
- Secondary parkinsonism;
- Parkinson-plus syndromes;
- MMSE score \<24;
- Participating in a aerobic exercise program;
- An unstable dosage of drugs active in the central nervous system (e.g., anxiolytics, antidepressants) during the 60 days before the baseline visit;
- Participation in drug studies or the use of investigational drugs within 30 days before screening; structural brain disease;
- Active epilepsy;
- Acute illness or active, confounding medical, neurological, or musculoskeletal conditions; alcoholism or other forms of drug addiction;
- Inability to complete the graded exercise test;
- Lack of medical clearance from our pulmonologist;
- Intention to move or take a \>1 month vacation during the study period;
- Contraindications to MRI or claustrophobia requiring sedation
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2012
Estimated Enrollment :
104 Patients enrolled
Trial Details
Trial ID
NCT00784563
Start Date
February 1 2009
End Date
May 1 2012
Last Update
September 15 2015
Active Locations (1)
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1
VA Medical Center, Iowa City
Iowa City, Iowa, United States, 52246-2208