Status:
COMPLETED
Is Insulin Resistance and/or Glucose Intolerance Pathogenetic in the Development of a Reduced Incretin Effect
Lead Sponsor:
University Hospital, Gentofte, Copenhagen
Conditions:
Insulin Resistance
Glucose Intolerance
Eligibility:
All Genders
20-70 years
Phase:
NA
Brief Summary
The purpose of this study is to examine whether there is a causal relationship between insulin resistance and/or glucose intolerance in the development of a defect incretin effect.
Detailed Description
In this study we are going to examine the incretin effect before and after the development of insulin resistance and/or glucose intolerance. The incretin effect is the increased insulin response seen ...
Eligibility Criteria
Inclusion
- Caucasians \>20 years
- Normal glucose tolerance as assessed by the WHO criteria
- First degree relative and at least 1 second degree relative with type 2 diabetes
- Normal haemoglobin
- Informed consent
Exclusion
- Liver disease (ALAT/ASAT \> 2 times normal value)
- Kidney disease (S-creatinin \> 130uM and/or albuminuria)
- Heart disease (NYHA II, III or IV)
- Treatment with medicine that cannot be paused
- Pregnancy of breast feeding
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2009
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT00784745
Start Date
November 1 2008
End Date
September 1 2009
Last Update
May 21 2014
Active Locations (1)
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1
Bispebjerg Hospital
Copenhagen, Denmark, 2300