Status:
COMPLETED
AC6 Gene Transfer for CHF
Lead Sponsor:
Hammond, H. Kirk, M.D.
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Renova Therapeutics
Conditions:
Congestive Heart Failure
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
PHASE2
Brief Summary
This research study is designed to determine: 1) whether gene transfer using an agent called Ad5.hAC6 (adenovirus-5 encoding human adenylyl cyclase type 6) can be given safely to patients with congest...
Detailed Description
This research study is designed to determine: 1) whether gene transfer using an agent called Ad5.hAC6 (adenovirus-5 encoding human adenylyl cyclase type 6) can be given safely to patients with congest...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Male or non-pregnant female patients aged 18-80 years of age
- ≥3-month history of heart failure
- Compensated (stable) CHF not on intravenous inotropes, vasodilators or diuretics, on optimal medical and device therapy as defined by AHA/ACC Guidelines
- LV ejection fraction (on optimal therapy) no greater than 40%
- Implanted cardiac defibrillator
- At least one major coronary artery (or graft) with \<50% proximal obstruction
- Patients unable to walk (spinal injury, orthopedic problems) can be enrolled if all other criteria are met.
- Women of child-bearing capacity must have a negative pregnancy test within 2 days of test substance administration, and female and male patients must be willing to use birth control during sex for 12w after test substance administration if the female partner is of child-bearing capacity.
- Subjects willingly provide informed consent consistent with ICH-GCP guidelines
- Exclusion Criteria
- Unstable or Class IV angina
- Coronary revascularization planned or predicted in next 6 months
- Ischemic myocardium in 3 or more regions of a single perfusion bed, as assessed by stress echocardiography or jeopardized viable myocardium \>15% on perfusion imaging.
- ≥50% occlusion of an "unprotected" left main coronary artery. If arterial or venous conduits provide blood flow to the distal left coronary circulation (ie, patent bypass grafts) then left main disease is "protected" and such patients are not excluded. The cardiologist performing the cardiac catheterization will make these decisions.
- 2° AV Block (Mobitz 2) or 3° AV block unless pacemaker is present
- Hospitalization for CHF requiring intravenous inotropes or vasodilators in the past 4 weeks
- History of biopsy proven myocarditis
- Myocardial infarction in previous 6 months
- Restrictive, hypertrophic or infiltrative cardiomyopathy or chronic pericarditis
- Previous or planned organ transplant recipient or donor.
- Thrombocytopenia (\<100,000 platelets/µl) or bleeding diathesis
- COPD requiring supplemental oxygen at home
- AST \> 2 times upper limit of normal or chronic liver disease such as cirrhosis or Hepatitis C Virus (HCV). Patients with HCV are eligible only if both of two conditions are met: a) liver function tests are normal; AND b) liver biopsy is normal or shows only mild fibrosis.
- Current or predicted hemodialysis within 12 months or estimated glomerular filtration rate (EGFR) \<30 ml/min. On online EGFR calculator that uses sex, age, body weight and serum creatinine is available at: www.kidney.org/professionals/kdoqi/gfr\_calculator.cfm. Use the higher of two EGFR results, which are based upon MDRD and CKD-EPI formulas.
- CVA or TIA \<6 months prior to enrollment
- Patients who are immunosuppressed by medicines (corticosteroids, methotrexate, cyclophosphamide, cyclosporine), illnesses (AIDS, HIV), or neutrophil count \<1000/mm3
- Patients receiving other investigational drug therapy within 30 days of enrollment including gene transfer
- Patients with diseases other than CHF that, in the opinion of the investigator, put the subject at risk or adversely affect the results
Exclusion
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 16 2017
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT00787059
Start Date
July 1 2010
End Date
November 16 2017
Last Update
February 9 2018
Active Locations (7)
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1
University of California, San Diego
San Diego, California, United States, 92037
2
VA San Diego Healthcare System
San Diego, California, United States, 92161
3
Northwestern University Feinberg School of Medicine
Chicago, Illinois, United States, 60611
4
Minneapolis Heart Institute Foundation
Minneapolis, Minnesota, United States, 55407