Status:
COMPLETED
N-Acetyl Cysteine After Cervical Cerclage
Lead Sponsor:
Assiut University
Conditions:
Cervical Cerclage
Eligibility:
FEMALE
20-35 years
Phase:
NA
Brief Summary
The aim of the study is to evaluate the effect of N-acetyl cysteine (NAC) on pregnancy outcome in women undergoing cervical cerclage for cervical insufficiency.
Detailed Description
A randomized controlled clinical trial to be carried out in a university-affiliated tertiary center.Participating women will be randomized into two groups: Group A will be given an oral daily dose of ...
Eligibility Criteria
Inclusion
- women with history suggestive of cervical insufficiency together with ultrasound findings suggestive of cervical insufficiency undergoing elective cervical cerclage between the 11th and 12th gestational week.
- singelton viable fetus
Exclusion
- women tested positive for bacterial vaginosis
- women currently with threatened abortion (vaginal bleeding or uterinecramps)
- age older than 35 years or younger than 20 years
- unwillingness to participate
- irregular and/or uncertain menstrual dates
- rupture of membranes
- previous cesarean delivery
- possible risks for preterm birth in the current or previous pregnancy such as twin pregnancy, IUFD, malpresentation, known fetal anomaly, progesterone or heparin treatment during the current pregnancy, hypertension, and/or seizure disorders.
- women with contra indications for cervical cerclage or anesthesia.
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2008
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00787813
Start Date
June 1 2008
End Date
November 1 2008
Last Update
November 20 2008
Active Locations (1)
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1
Women's Health Center
Asyut, Asyut Governorate, Egypt, 71516