Status:
COMPLETED
Exploratory Positron Emission Tomography (PET) Study to Evaluate the Effects of ABT-614 on [11C]-(+)-PHNO Binding Potential to D3 Receptors in the Brain
Lead Sponsor:
Abbott
Conditions:
Healthy Volunteers
Eligibility:
MALE
18-40 years
Phase:
PHASE1
Brief Summary
This study is being done in healthy volunteers to help researchers understand how ABT-614 works in the human body, specifically in the brain. The PET imaging technique can be thought of as a way to ta...
Eligibility Criteria
Inclusion
- Body Mass Index (BMI) is 18 to 26 kg/m2, inclusive
- A condition of general good physical health based upon the results of a medical history, physical examination, vital signs, laboratory profile, 12-lead electrocardiogram (ECG)
Exclusion
- Presence of a metal implant (i.e., aneurysm clip, metal fragments, internal electrical devices such as a cochlear implant, spinal cord stimulator or pacemaker) that would preclude a MRI scan
- During the last year, a radiation exposure that on its own or in addition to the expected radiation from this study exceeds the allowed annual radiation exposition level (20 mV)
- Use of tobacco or other nicotine-containing products within 6 months prior to Screening
- Diagnosis of substance or alcohol disorder within 12 months prior to Screening
- History of claustrophobia or feeling of inability to lie still on his back in the PET camera
- History or presence of any neurological or psychiatric conditions
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT00788801
Start Date
December 1 2008
Last Update
November 2 2010
Active Locations (2)
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1
Site Reference ID/Investigator# 12201
Toronto, Ontario, Canada, M5T 1R8
2
Site Reference ID/Investigator# 13961
Toronto, Ontario, Canada, M5V 2T3