Status:
COMPLETED
Masitinib in Combination With Gemcitabine for Treatment of Patients With Advanced/Metastatic Pancreatic Cancer
Lead Sponsor:
AB Science
Conditions:
Pancreatic Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The objective of this study is to compare the efficacy and safety of masitinib in combination with gemcitabine to placebo in combination with gemcitabine in patients with advanced/metastatic pancreati...
Detailed Description
Human pancreatic cancer overexpresses a number of important tyrosine kinase (TK) growth factors receptors and ligands, including expression of both PDGF and PDGF receptors. Drugs that can selectively ...
Eligibility Criteria
Inclusion
- Main
- Histologically or cytologically confirmed adenocarcinoma of the pancreas
- Chemo naïve patients with advanced/metastatic disease
- Documented decision justifying non eligibility for surgical resection. The documentation of the non eligibility for surgical resection will be reviewed by an independent committee.
- Men and women, age \>18 years
- Men and women of childbearing potential (entering the study after a confirmed menstrual period and who have a negative pregnancy test), must agree to use two methods (one for the patient and one for the partner) of medically acceptable forms of contraception during the study and for 3 months after the last treatment intake.
- Patient should be able and willing to comply with study visits and procedures as per protocol.
- Patient should understand, sign, and date the written voluntary informed consent form at the screening visit prior to any protocol-specific procedures performed.
- Main
Exclusion
- Patient treated for a cancer other than pancreatic cancer within 5 years before enrollment, with the exception of basal cell carcinoma or in situ cervical cancer
- Any condition that the physician judges could be detrimental to subjects participating in this study; including any clinically important deviations from normal clinical laboratory values or concurrent medical events Previous treatment
- Any anti-tumor therapy (any chemotherapy, radiotherapy, immunotherapy, biologic or hormonal therapy) within 6 months prior to baseline
- Treatment with any investigational agent within 4 weeks prior to baseline
Key Trial Info
Start Date :
November 25 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2012
Estimated Enrollment :
353 Patients enrolled
Trial Details
Trial ID
NCT00789633
Start Date
November 25 2008
End Date
August 31 2012
Last Update
December 17 2018
Active Locations (68)
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1
Eastern Connecticut Hematology and Oncology (ECHO)
Norwich, Connecticut, United States, 06360
2
MD Anderson
Orlando, Florida, United States, 32806
3
The Emory Clinic
Atlanta, Georgia, United States, 30322
4
Decatur Memorial Hospital
Decatur, Illinois, United States, 62526