Status:
COMPLETED
Anakinra to Prevent Post-infarction Remodeling
Lead Sponsor:
Virginia Commonwealth University
Conditions:
ST Segment Elevation Acute Myocardial Infarction
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Thousands of patients die daily from early and late complications of a heart attack (acute myocardial infarction, AMI). Patients surviving AMI remain at high risk of death from adverse cardiac remodel...
Eligibility Criteria
Inclusion
- Age \>18 years
- Acute (\<24 hours) onset of chest pain
- New or presumably new ST elevation on ECG
- Planned coronary angiography for percutaneous revascularization
Exclusion
- Inability to give informed consent
- Late presentation (\>24 hours)
- Unsuccessful revascularization or urgent coronary bypass surgery
- Hemodynamic instability
- End-stage congestive heart failure (AHA/ACC stage C/D, NYHA class IV)
- Preexisting severe LV dysfunction (LVEF\<20%) or severe valvular disease
- Severe asthma
- Pregnancy ( pre-enrollment pregnancy test)
- Contraindications to cardiac MRI or cardiac angiography
- Severe coagulopathy (INR\>2.0, Platelet count\<50,000/mm3)
- Severe renal insufficiency (creatinine clearance \<30 ml/min/m2)
- Recent (\<14 days) use of anti-inflammatory drugs (NSAIDS excluded)
- Chronic inflammatory disease
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2009
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00789724
Start Date
November 1 2008
End Date
August 1 2009
Last Update
November 30 2017
Active Locations (1)
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1
Virginia Commonwealth University
Richmond, Virginia, United States, 23298