Status:
COMPLETED
Fondaparinux Trial With Unfractionated Heparin (UFH) During Revascularization in Acute Coronary Syndromes (ACS)
Lead Sponsor:
GlaxoSmithKline
Conditions:
Acute Coronary Syndrome
Eligibility:
All Genders
21+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare the safety of two different dose regimens of unfractionated heparin (UFH) during a percutaneous coronary intervention (PCI) procedure in patients with UA (unsta...
Detailed Description
Subjects presenting at hospital with suspected UA or NSTEMI and who are likely to undergo angiography (ideally within 72 hours) will be assessed for eligibility and consented. Suitable subjects will b...
Eligibility Criteria
Inclusion
- The following are inclusion and exclusion criteria for enrollment in the study:
- Presenting or admitted to hospital with symptoms suspected to represent UA or NSTEMI, i.e., clinical history consistent with new onset, or a worsening pattern of, characteristic ischemic chest pain or ischemic symptoms occurring at rest or with minimal activity (lasting longer than 5 minutes or requiring sublingual nitro-glycerine for relief of the pain).
- Available to be enrolled within 48 hours of the onset of the most recent episode of symptoms.
- Planned coronary angiography, with PCI if indicated, within 72 hours of enrollment where possible.
- At least two of the three following additional criteria:
- Age greater than or equal to 60 years
- Troponin T or I or CK-MB above the upper limit of normal for the local institution;
- Electrocardiogram (ECG) changes compatible with ischemia, i.e., ST depression at least 1 mm in 2 contiguous leads or T wave inversion \> 3 mm or any dynamic ST shift or transient ST elevation.
- Written informed consent dated and signed
Exclusion
- Age \< 21 years.
- Any contraindication to UFH or fondaparinux
- Contraindication for angiography or PCI at baseline
- Subjects requiring urgent (\<120 minutes) coronary angiography as characterized by those with:
- refractory or recurrent angina associated with dynamic ST-deviation
- heart failure
- life-threatening arrhythmias
- hemodynamic instability
- Subjects already receiving treatment with enoxaparin (or other LMWH), bivalirudin or UFH for treatment of the qualifying events unless the last administered (intravenous(i.v.) or s.c.) dose was:
- ≥ 8 hours for low molecular weight heparin (LMWH)
- ≥60 minutes for bivalirudin
- ≥90 minutes for unfractionated heparin (UFH)
- Hemorrhagic stroke within the last 12 months.
- Indication for anti-coagulation other than acute coronary syndrome (ACS) during the index hospitalization.
- Pregnancy or women of childbearing potential who are not using an effective method of contraception.
- Co-morbid condition with life expectancy less than 6 months.
- Currently receiving an experimental pharmacological agent.
- Revascularization procedure already performed for the qualifying event.
- Severe renal insufficiency (i.e., estimated creatinine clearance \<20 ml/min)
- Following angiography and confirmation that the subject is to undergo PCI, the subject must also meet all of the following additional criteria in order to be randomised:
- Subjects will have received at least 1 dose of open-label fondaparinux
- The most recent dose of open-label fondaparinux will not have been more than 24 hours before the start of the PCI procedure.
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2010
Estimated Enrollment :
3235 Patients enrolled
Trial Details
Trial ID
NCT00790907
Start Date
February 1 2009
End Date
May 1 2010
Last Update
March 23 2017
Active Locations (203)
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1
GSK Investigational Site
Ocala, Florida, United States, 34471
2
GSK Investigational Site
Albuquerque, New Mexico, United States, 87106
3
GSK Investigational Site
Syracuse, New York, United States, 13210
4
GSK Investigational Site
Dallas, Texas, United States, 75216