Status:
TERMINATED
The Effect of Pancreatic Polypeptide on Insulin Requirements for Type 1 & Post-pancreatectomy Diabetic Patients
Lead Sponsor:
Johns Hopkins University
Conditions:
Diabetes Mellitus, Type 1
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
Brief Summary
The goal of this research is to see if pancreatic polypeptide (PP), a hormone that is naturally produced by the pancreas and that works to control the amount of glucose that the liver makes, will redu...
Detailed Description
The pancreas is a large gland located behind the stomach. One of the functions of the pancreas is to produce two hormones: insulin and pancreatic polypeptide. Insulin helps the cells to take in glucos...
Eligibility Criteria
Inclusion
- Male and female volunteers between the ages of 18-75 with:
- 10 subjects who are status post pancreatic resection and 10 volunteers who are Type 1 diabetic for \> 8 years (volunteers must have a stable glycemic profile that includes use of an insulin pump to control their blood glucose) with or without prior pancreatic resection.
- HbA1c levels ≤ 8.5.
Exclusion
- Lactating or pregnant females.
- Brittle or Labile diabetics: Volunteers with extremely erratic patterns of glucose control with large fluctuations in glucose levels for no obvious reason.
- Allergy to beef or beef by-products.
- Hypoglycemia within the past year requiring medical or other assistance to correct.
- Known autonomic neuropathy.
- Documented blood glucose under 60 mg within the past year and hypoglycemic unawareness.
- Durations of type 1 Diabetes Melitis (DM) ≤ 8 years.
- Not currently on pump therapy.
- Type 1 DM who has a BMI ≥ 35.
Key Trial Info
Start Date :
October 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2010
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT00791076
Start Date
October 1 2007
End Date
June 1 2010
Last Update
July 12 2017
Active Locations (1)
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1
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21224