Status:
COMPLETED
The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids in Asthma
Lead Sponsor:
Mahidol University
Conditions:
Asthma
Eligibility:
All Genders
18-70 years
Phase:
PHASE3
Brief Summary
We hypothesize that simvastatin in combination with ICS might have synergistic anti-inflammatory effects on airway inflammation in asthmatic patients
Detailed Description
To determine the additive effect of simvastatin on airway inflammation in ICS-treated patients with persistent asthma by measuring eosinophil counts in induced sputum
Eligibility Criteria
Inclusion
- He or she has FEV1 \> 60% of predicted
- He or she requires less than 1000 mcg daily of beclomethasone or equivalent
Exclusion
- He or she had previous history of renal disease or serum creatinine more than 2 mg/dL
- He or she had previous history of liver disease
- She is pregnant or during lactation
- He or she has already received statins or is allergic to statins or has developed myositis.
- He or she has an asthma exacerbation and requires treatment with oral corticosteroids during the 3 months prior to the commencement of study entry.
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2009
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT00792337
Start Date
December 1 2008
End Date
September 1 2009
Last Update
September 11 2013
Active Locations (1)
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1
Kittipong Maneechotesuwan
Bangkoknoi, Bangkok, Thailand, 10700