Status:
COMPLETED
Omega-3 Fatty Acids and Muscle Protein Synthesis
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
Longer Life Foundation
American Federation for Aging Research
Conditions:
Healthy
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether omega-3 fatty acid supplementation influences muscle protein synthesis rates in young and older adults.
Detailed Description
Loss of muscle mass is a normal consequence of aging. The decline in muscle mass is estimated to be 0.2-0.5% per year from 60 years old onwards in healthy subjects with the decline worsened by chronic...
Eligibility Criteria
Inclusion
- Body mass index (BMI) \< 30 kg/m2;
- Age 18-45 yr; or
- Age 65-85 yr
Exclusion
- Those taking medications known to affect substrate metabolism or medications that may confound the findings from our study (synthetic steroids, glucocorticoids etc.);
- Those with evidence of significant organ system dysfunction (e.g. diabetes mellitis, cirrhosis, hypo- or hyperthyroidism; hypertension);
- Body mass index \> 30 kg/m2
- Age \<18 yr, 45-65 yr or \> 85 yr
- Those performing \>1.5h of exercise/wk
Key Trial Info
Start Date :
June 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT00794079
Start Date
June 1 2007
End Date
December 1 2010
Last Update
August 3 2011
Active Locations (1)
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1
Washington University in Saint Louis
St Louis, Missouri, United States, 63110