Status:
UNKNOWN
The Effect of Remote Ischemic Preconditioning in Patients Undergoing Major Liver Surgery
Lead Sponsor:
Royal Free Hampstead NHS Trust
Conditions:
Ischemia Reperfusion Injury
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
The project has been designed to determine whether a brief period of leg ischemia will reduce the I/R injury sustained by the liver during liver surgery and liver transplantation. Adult patients (aged...
Detailed Description
Data Collection \& Measurements: Blood Measurements: Blood will be collected at seven different time points, Baseline, Post IPC, 15 and 90 minutes post IRI and then 6,12 and 24 hours post IRI. At eac...
Eligibility Criteria
Inclusion
- Patients above the age of 18 undergoing liver surgery
Exclusion
- Absence of written, informed consent.
- Patients with symptomatic peripheral vascular disease and absent or weak peripheral pulses.
- Patients with varicose veins and venous ulcers
- Patients with blood disorders, eg. sickle cell disease
- Patients with any localised limb infections eg. cellulitis
- Pregnancy
- HIV infection
- Fulminant sepsis
- Severe comorbid disease
- Patients below the age of 18
Key Trial Info
Start Date :
April 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2012
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT00796588
Start Date
April 1 2005
End Date
December 1 2012
Last Update
November 24 2008
Active Locations (1)
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1
Royal Free Hospital
London, United Kingdom, NW3 2QG