Status:
COMPLETED
Salt Study: Inhibited Breathing Pattern and Sodium Inhibitors in Sodium Sensitivity of Blood Pressure
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Hypertension
Eligibility:
All Genders
40-70 years
Brief Summary
The purpose of this study is to test the hypothesis that blood pressure sensitivity to high sodium intake in healthy humans is characterized by increased urinary excretion of two endogenous sodium pum...
Detailed Description
The experiments will involve a common procedure of sodium restriction followed by sodium loading of normotensive (having normal blood pressure) humans. However, the first experiment will involve conti...
Eligibility Criteria
Inclusion
- Age 40-70
- Caucasian
- Nonsmoking
- Free of respiratory, cardiac, liver and kidney disease, and diabetes
- Resting systolic blood pressure less than or equal to 139 mmHg AND resting diastolic blood pressure of less than or equal to 89 mmHg15
- BMI less than or equal to 30
- Negative pregnancy test for female participants whose last menstrual period was less than one year prior to study enrollment
- For Group 1, willing to provide 24-hr urine samples for 12 consecutive days
- For Group 2, women on combination oral contraceptives (those containing estrogen and progesterone) will be eligible for the study, with equal numbers in the "fast" and "slow" breathing groups
- For Group 2, in premenopausal women, regular menstrual cycles for at least 6 months prior to study entry
Exclusion
- Presence of respiratory, cardiac, liver or kidney disease; diabetes, or hypertension
- Use of medications which can affect respiratory rate, such as major tranquilizers, narcotics, or benzodiazepines
- Diuretic or steroid use
- Cigarette smoking within the past 12 months
- BMI \> 30 kg/m2
- Postmenopausal women on hormone replacement therapy
- Pregnancy or lactation in the last 12 months
- In premenopausal women, irregular menstrual cycles in the 6 months prior to study entry
- For Group 2, respiratory rate in the middle third of the distribution of breathing frequency in BLSA
- For Group 2, pre-menopausal women not taking oral contraceptives who are in the follicular phase of the menstrual cycle
Key Trial Info
Start Date :
March 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2006
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT00800228
Start Date
March 1 2003
End Date
December 1 2006
Last Update
December 2 2008
Active Locations (1)
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1
NIA Clinical Research Unit
Baltimore, Maryland, United States, 21225