Status:
COMPLETED
Effects of Levosimendan on Microcirculation in Septic Shock
Lead Sponsor:
University of Roma La Sapienza
Conditions:
Septic Shock
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The present study was conducted as a prospective, randomized, controlled study to: * investigate the effects of a combination of levosimendan and inhaled nitric oxide on systemic hemodynamics and mic...
Detailed Description
40 septic shock patients requiring norepinephrine to maintain mean arterial pressure between 65 and 75 mmHg despite adequate volume resuscitation will be enrolled in the study. After an initial hemody...
Eligibility Criteria
Inclusion
- Clinical diagnosis of Septic shock
- Vasopressor support to maintain mean arterial pressure (MAP) between 65 and 75 mmHg despite adequate volume resuscitation (pulmonary artery occlusion pressure = 13-18 mmHg and central venous pressure = 8-12 mmHg)
Exclusion
- Pregnancy
- Age \< 18 years
- Ventricular outflow tract obstruction
- Mitral valve systolic anterior motion
Key Trial Info
Start Date :
November 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2009
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00800306
Start Date
November 1 2007
End Date
April 1 2009
Last Update
October 15 2009
Active Locations (1)
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1
Departement of Anesthesiology and Intensive Care of the University of Rome "La Sapienza" Viale del Policlinico 155
Rome, Italy, 00161