Status:
COMPLETED
The Combination Effect of Dexmedetomidine and Morphine in Postoperative Patient-Controlled Analgesia
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Analgesia, Patient-Controlled
Analgesia, Postoperative
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
This study was designed to examine the analgesic and side effects of dexmedetomidine-morphine mixture for intravenous patient-controlled analgesia (PCA).
Detailed Description
Patient-controlled analgesia (PCA) is a widely accepted method to control postoperative pain. Morphine is the commonest opioid for PCA, however its side effects are troublesome. Morphine-related side ...
Eligibility Criteria
Inclusion
- Patients who sign informed consent to receive general anesthesia and postoperative analgesia with a PCA device
- Age between 18-65 y/o
- ASA physical status I-III
- Scheduled surgical procedures: gynecological surgery (vaginal or abdominal total hysterectomy), general surgery (gastrectomy, hepatectomy, colon cancer) , orthopedic (spinal fusion or total knee placement), or neurosurgical (cervical decompression)
Exclusion
- Patients with a definite diagnosis of chronic pain syndrome, psychiatric disorders, or drug abuse (include opioids, NSAIDs, sedatives, antidepressants).
- Use of sedatives, analgesics, antiemetics, or antipruritics within 24 hours before operation.
- Patients with definite diagnosis of esophageal reflux syndrome.
- Patients with the probability to be pregnant.
- Intraoperative fentanyl use \> 6 μg/kg.
- Patients with significant bradycardia (HR \< 60/min) and hypotension (SBP \< 90mmHg) after the surgery.
- The duration of surgery is longer than 6 hours.
Key Trial Info
Start Date :
November 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2008
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00800826
Start Date
November 1 2006
End Date
April 1 2008
Last Update
December 2 2008
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