Status:
COMPLETED
Dopamine and Insulin Resistance
Lead Sponsor:
Vanderbilt University
Conditions:
Obesity
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Obese individuals have fewer striatal dopamine type 2 receptors (DRD2) than normal weight individuals. Lower DRD2 levels are associated with addiction and a decreased sense of pleasure.Obesity is also...
Detailed Description
In has been reported obese individuals have fewer striatal dopamine type 2 receptors (DRD2) compared to normal weight individuals congruent with diet induced obese rodent models and similar to models ...
Eligibility Criteria
Inclusion
- Ages 18-60 yrs
- obese BMI \> 30kg/m2 and Weight less than 350 lbs
- lean control BMI 18-25kg/m2
Exclusion
- Structured exercise \> equivalent to 30mins 5x week of walking times a week
- History of Substance Abuse, including but exclusive to alcohol, cocaine, marijuana, heroin, nicotine
- Current psychiatric disorder or significant h/o disorder
- Use or any antidepressants or antipsychotics for last 3-6months or depot antipsychotics in the last 12 months
- Any condition felt by PI or co-investigators to interfere with ability to complete the study
- Inability to abstain from alcohol, physical exercise or \> 1 cup of coffee or equivalent daily for 3 days prior to imaging studies
- Significant co-morbidities including atherosclerotic disease, metabolic disease, liver or renal insufficiency or abnormality found on MRI
- Any condition which would interfere with MRI or PET studies, e.g. claustrophobia, cochlear implant, metal fragments in eyes, cardiac pacemaker, neural stimulator, tattoos with iron pigment and metallic body inclusions or other metal implanted in the body which may interfere with MRI scanning
- Subjects on medications determined by PI, ex. sibutramine, frequent benzodiazepines or related drugs, which could affect quality of study for last 3 months.
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT00802204
Start Date
December 1 2008
End Date
December 1 2012
Last Update
May 10 2017
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232