Status:
COMPLETED
Automatic Tube Compensation (ATC) for Weaning Patients With Severe Neurotoxic Snake Envenoming
Lead Sponsor:
Post Graduate Institute of Medical Education and Research, Chandigarh
Collaborating Sponsors:
Dept of Pulmonary Medicine, PGIMER, Chandigarh
Conditions:
Snake Bite
Weaning
Eligibility:
All Genders
Phase:
NA
Brief Summary
In the mechanically ventilated patient, the single greatest cause of imposed work of breathing is the resistance caused by the endotracheal tube. Commonly used maneuvers to overcome this resistance in...
Detailed Description
Snake envenoming is a common medical emergency encountered in the tropical countries, and an estimated 35,000 to 50,000 people die of snake bite every year in India. The bites of Elapid snakes cause p...
Eligibility Criteria
Inclusion
- Patients with severe neurotoxic snake envenoming (defined as requirement of mechanical ventilation for ventilatory failure) will be included in the study. - Snake envenoming will be diagnosed on the history of snakebite, presence of fang marks, presence of local manifestations such as swelling, cellulitis, blister formation; or if the dead snake is brought for identification.
- Significant improvement in the neuroparalysis with improvement in grade of power to at least MRC 3
- Normal sensorium
- Minimal suction requirements (less than thrice in the eight hours preceding the assessment
- No requirement for any vasoactive drugs
- No sedation (vi) core temperature less than 38.0°C
- Hemoglobin more than 9 gm/dL (viii) systolic blood pressure more than 90 mm Hg
- Overall physician assessment whether the patient is fit for weaning.
Exclusion
- If they do not meet the inclusion criteria
Key Trial Info
Start Date :
July 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2008
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT00804011
Start Date
July 1 2004
End Date
April 1 2008
Last Update
December 8 2008
Active Locations (1)
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1
Department of Pulmonary Medicine
Chandigarh, Uttarakhand, India, 160012