Status:
UNKNOWN
Autologous Stem Cell Transplant (ASCT) With Intravenous Busulfan and Melphalan as Conditioning Regimen
Lead Sponsor:
Fundacion Para La Investigacion Hospital La Fe
Conditions:
Multiple Myeloma
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
Analyze the results of ASCT using intravenous Busulfan and Melphalan as conditioning regimen for patients with Multiple Myeloma.
Detailed Description
Primary Efficacy and safety of the procedure in terms of number of remissions, survival, event-free survival, relapse risk, and early transplant-related mortality (up to day +100). Secondary Graft ki...
Eligibility Criteria
Inclusion
- Symptomatic multiple myeloma
- Male or female subject age \>= 70 years
- The subject has received at least one previous line of therapy including:
- Front-line treatment with VBMCP/VBAD or VAD or second-line therapy with regimens including bortezomib, thalidomide or lenalidomide
- The subject has given voluntary written informed consent
Exclusion
- Use of bortezomib, thalidomide or lenalidomide as front-line therapy
- ECOG satus \>=2
- Left ventricular ejection fraction \<40%
- DLCO and FVC \<39% theoretical value
- Abnormal liver function(total bilirubin \> 2 mg/dL and/or ALT or AST \> 3 x ULN)
- Serum creatinine at transplant \>1.6 mg/dL and/or creatinine clearance \< 65 mL/minute
- Subject has an active systemic infection requiring treatment
- Subject had a myocardial infarction within 6 months of enrollment or has NYHA Class III or IV heart failure, uncontrolled angina, severe uncontrolled ventricular arrythmias
- Subject has any other serious medical condition (severe hepatic impairment, pericardial disease, acute diffuse infiltrative pulmonary disease) or psychiatric illness that could potentially interfere with the completion of treatment of this protocol
- Subject is known to be immunodeficiency virus (HIV)-positive
- Subject has received an experimental drug or used and experimental medical device within 4 weeks before enrollment
- If female, the subject is pregnant or breast-feeding. Confirmation that the subject is not pregnant must be established by a negative pregnancy test at screening. Pregnancy testing is not required for postmenopausal or surgically sterilized women
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2010
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00804947
Start Date
September 1 2005
End Date
March 1 2010
Last Update
December 9 2008
Active Locations (6)
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1
Hospital Insular Canarias
Las Palmas de Gran Canaria, Las Palmas, Spain
2
H La Princesa
Madrid, Madrid, Spain
3
H. 12 de Octubre
Madrid, Madrid, Spain
4
S. de Hematología. Hospital La Fe
Valencia, Valencia, Spain, 46009