Status:
UNKNOWN
Cardiac Magnetic Resonance Imaging for Detecting Endothelial Dysfunction
Lead Sponsor:
University of California, Los Angeles
Collaborating Sponsors:
Bracco Diagnostics, Inc
Conditions:
Endothelial Dysfunction
Myocardial Perfusion Abnormalities
Eligibility:
All Genders
18-50 years
Brief Summary
The goal of this research study is to demonstrate that Cardiac Perfusion MRI with Vasomotor Stress may serve as a non-invasive and less risky imaging technique for detecting non-obstructive perfusion ...
Eligibility Criteria
Inclusion
- Age 18 to 50 years
- Should be able to sign an informed consent and HIPAA Agreement
- 30 healthy, non-diabetic individuals
- 30 diabetic individuals without documented coronary artery disease
- Diagnosed diabetics less than 5 years
- HbA1c less than 8.0
Exclusion
- Children under 18 years and adults above 50 years
- Type 1 DM
- Lactating and Pregnant females
- BMI less than 35
- Contraindication to MRI such as pacemaker, defibrillator implants, etc.
- Allergy to MR (paramagnetic) contrast
- History of Angina, MI, or documented Coronary Artery Disease
- Previous history of CHF, CABG, Angioplasty and Stenting
- History of Valvular Heart Disease and Congenital Heart Disease
- History of Peripheral Vascular Disease
- History of Cardiac Arrythmias and anti-coagulation therapy
- History of Cerebro-vascular accidents or TIA
- History of active diabetic retinopathy and nephropathy
- Uncontrolled hypertension (systolic \> 170 and diastolic \>100 mm Hg
- End Stage Renal Disease and patients on dialysis
- HbA1c of 8.0
- Creatinine greater than 1.7 mg/dl
- History of active gastrointestinal bleeding
- History of IV drug use
- Chronic or current steroid treatment
- Growth hormone treatment
Key Trial Info
Start Date :
February 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2010
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00808535
Start Date
February 1 2009
End Date
March 1 2010
Last Update
February 9 2009
Active Locations (1)
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1
UCLA Radiological Sciences
Los Angeles, California, United States, 91324