Status:
COMPLETED
Efficacy of High Dose atorvaSTATIN Loading Before Primary Percutaneous Coronary Intervention in ST Elevation Myocardial Infarction (STATIN STEMI)
Lead Sponsor:
Yonsei University
Conditions:
Myocardial Infarction
Angioplasty
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
Although statin prior to PCI has favorable effects in stable angina and ACS except ST elevation MI (STEMI), there have been few studies for STEMI. Celik T et al. reported in patients with STEMI that p...
Eligibility Criteria
Inclusion
- The patient must be at least 18 years and 80 years of age.
- The patient had the symptoms of acute myocardial infarction within 12 hours with ST segment elevation of more than 1 mm in at least two contiguous leads of EKG or new onset LBBB.
- The patient or guardian agrees to the study protocol and provides informed, written consent.
Exclusion
- Patients to whom PCI can not be undergone within 12 hours from receiving the study drug
- Cardiogenic shock or symptomatic hypotension or sitting SBP \< 95 mmHg
- The history of major surgery, trauma, retinal hemorrhage, significant gastrointestinal or genitourinary bleeding within recent 6 weeks; history of cerebrovascular attack within two years, or cerebrovascular attack with a significant residual neurological deficit
- History of cerebrovascular attack within two years, or cerebrovascular attack with a significant residual neurological deficit
- Severe or malignant hypertension (= sitting SBP \> 180 mmHg and/or sitting DBP \> 105 mmHg)
- The history or diagnosis of vasculitis; renal insufficiency (the level of serum creatinine is two times higher than the upper limit of normal of each center)
- The patients who might die of other disease than cardiac disease during the trial.
Key Trial Info
Start Date :
July 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
170 Patients enrolled
Trial Details
Trial ID
NCT00808717
Start Date
July 1 2007
Last Update
July 15 2009
Active Locations (1)
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1
Severance Hospital
Seoul, South Korea, 120-752