Status:
UNKNOWN
The Influence Of GIP (Glucose-Dependent Insulinotropic Polypeptide) Infusion On Human Adipose Tissue: An In Vivo Study
Lead Sponsor:
Liverpool University Hospitals NHS Foundation Trust
Conditions:
Adipose Tissue
Eligibility:
MALE
18-75 years
Phase:
NA
Brief Summary
Study part-1 GIP (glucose-dependent insulinotropic polypeptide) is one of the two main incretin hormones secreted by specialized cells of the gastrointestinal tract in response to ingestion of nutrie...
Eligibility Criteria
Inclusion
- Lean (BMI 20-25 kg/m2) subjects with normal glucose tolerance
- Obese (BMI \>30 kg/m2) subjects also with normal glucose tolerance.
- Obese with impaired glucose tolerance
- Obese with diet controlled diabetes mellitus
- Morbid obesity, type diabetes and post bariatric surgery (study part 2)
Exclusion
- History of severe cardiac, hepatic or renal disease
- Thyroid dysfunction (hyper-or hypothyroidism), or other endocrine disturbance (acromegaly, growth hormone deficiency, hypoadrenalism or cortisol overproduction)
- Current malignant disease
- Known alcohol misuse
- Major psychiatric disease (including current use of antidepressants)
- History of major eating disorder (anorexia or bulimia nervosa)
Key Trial Info
Start Date :
April 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2012
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00809029
Start Date
April 1 2011
End Date
December 1 2012
Last Update
December 21 2011
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospital Aintree
Liverpool, United Kingdom, L9 7AL