Status:
WITHDRAWN
In Vivo Assessment of Histamine Pharmacodynamics
Lead Sponsor:
Children's Mercy Hospital Kansas City
Conditions:
Histamine Biotransformation
Eligibility:
All Genders
7-18 years
Phase:
NA
Brief Summary
A critical first step to address the "pharmacodynamic information gap" in pediatrics resides with the development of methods capable of accurately measuring the time dependent effects of xenobiotic ex...
Detailed Description
The overall goal of this research is to develop and validate non-invasive approaches suitable for use in pediatrics that are sufficient to directly evaluate genotype-phenotype associations as determin...
Eligibility Criteria
Inclusion
- Male or female between ages of 7 and 18 years
- Diagnosed with allergic disease (i.e., allergic rhinitis, allergic conjunctivitis, allergic asthma)
- Informed consent (Parental permission and subject assent)
Exclusion
- Previous history or laboratory evidence of McCune Albright syndrome, immunodeficiency, mastocytosis, receipt of immunomodulatory treatment, chronic conditions associated with abnormalities of the integument, hepatic or renal compromise, neoplastic disease, movement or neurologic disorders and uncontrolled ADHD
- Evidence of atopic dermatitis within a 2 year period from the time of study
- History of previous anaphylactic or anaphylactoid episode
- Evidence of pregnancy (by urinary hCG) or lactation at the time of study
- Receipt of drugs (within a specified time period) of agents capable of altering the response to histamine provocation (e.g., antihistamines, systemic corticosteroids, tricyclic antidepressants)
- Presence of any condition that, in the opinion of the investigator, would produce difficulty with adherence to study procedures.
Key Trial Info
Start Date :
September 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2008
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00809692
Start Date
September 1 2007
End Date
September 1 2008
Last Update
January 7 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Children's Mercy Hospitals and Clinics
Kansas City, Missouri, United States, 64108